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CONTENTS |
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CONTENTS:-
1. Molecular Recognition in Ligand–Protein Binding, T. Liljefors
2. Biostructure-Based Drug Design, F. S. Jørgensen and J. S. Kastrup
3. Ligand-Based Drug Design, I. Pettersson, T. Balle, and T. Liljefors
4. Chemical Biology, K. Strømgaard
5.Stereochemistry in Drug Design, M. B. Mayo-Martin and D. E. Jane
6. Natural Products in Drug Discovery, G. T. Carter
7. Imaging in Drug Discovery and Development, M. Rudin and T. Mueggler
8. Peptides and Peptidomimetics, M. Cai, V. V. Kulkarni, and V. J. Hruby
9. Prodrugs: Design and Development, A. Buur and N. Mørk
10. Metals in Medicine: Inorganic Medicinal Chemistry, H. R. Hansen and O. Farver
11. Enzyme Inhibitors: Biostructure-Based and Mechanism- Based Designs, R. A. Copeland, R. R. Gontarek, and L. Luo
12. Receptors: Structure, Function, and Pharmacology, H. Bräuner-Osborne
13. Ion Channels: Structure and Function, S.-P. Olesen and D. B. Timmermann
14. Neurotransmitter Transporters: Structure and Function, C. J. Loland and U. Gether
15. GABA and Glutamic Acid Receptor Ligands, B. Frølund and U. Madsen
16. Acetylcholine, A. A. Jensen and P. Krogsgaard-Larsen
17. Histamine Receptors, I. de Esch, H. Timmerman, and R. Leurs
18. Dopamine and Serotonin, B. Bang- Andersen and K. P. Bøgesø
19. Opioid and Cannabinoid Receptors, R. P. Clausen and H. S. Hansen
20. Hypnotics, B. Ebert and K. A. Wafford
21. Neglected Diseases, S. B. Christensen
22. Immunomodulating Agents, U. G. Sidelmann
23. Anticancer Agents, F. Björkling and L. H. Jensen
24. Antiviral Drugs, E. De Clercq
25. Antibiotics, P. Herdewijn |
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DESCRIPTION |
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| Updated and revised, this fourth edition of a perennial bestseller provides current and comprehensive information on all aspects of drug design and discovery. It describes how medicinal chemists the specific strategies employed by medicinal chemists to advance promising molecules into clinical use for the alleviation of disease. The fourth edition includes new chapters on products of natural origin as leads in drug design, chemical biology, ADME-tox properties, bioinformatics and chemoinformatics in drug research, combinatorial chemistry, parallel synthesis, high-throughput screening, imaging in drug design, computer modeling techniques, gene technology, and target validation. |
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